Bullous Systemic Lupus Erythematosus

Bullous systemic lupus erythematosus: differential diagnosis with dermatitis herpetiformis.

An Bras Dermatol. 2011 Jul-Aug;86(4 Suppl 1):S92-5

Authors: Barbosa WS, Rodarte CM, Guerra JG, Maciel VG, Fleury Júnior LF, Costa MB

Abstract
Bullous systemic lupus erythematosus is a rare subset of systemic lupus erythematosus that is even rarer in pediatric patients. We report a case of a 12-year-old girl who presented with a vesiculobullous eruption on her face, neck, trunk and genital and oral mucosa, as well as anemia, sterile pyuria, ANA (1:1280, speckled pattern) and positive anti-Sm and anti-RNP.

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Pathological examination suggested dermatitis herpetiformis, and direct immunofluorescence revealed IgG, IgA and fibrin in the epithelial basement membrane zone. We present a typical case of bullous systemic lupus erythematosus and emphasize the importance of clinical and histopathological differential diagnosis with dermatitis herpetiformis.

PMID: 22068782 [PubMed – indexed for MEDLINE]

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