Researchers identify novel pathophysiologic mechanism responsible for autoimmunity

Researchers have discovered that human proteins with an affinity for dermatan sulfate (DS) have the propensity to become autoantigens. In a companion article, the researchers also found that DS physically interacts with dead cells and that the resulting DS-autoantigen complexes drive autoreactive B-1a cell responses and autoantibody production both in-vitro and in mouse models.

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