RP105-negative B cells in systemic lupus erythematosus.

RP105-negative B cells in systemic lupus erythematosus.

Clin Dev Immunol. 2012;2012:259186

Authors: Koarada S, Tada Y

Systemic lupus erythematosus (SLE) is a multisystem disease characterized by B cells producing autoantibodies against nuclear proteins and DNA, especially anti-double-strand DNA (dsDNA) antibodies. RP105 (CD180), the toll-like receptor- (TLR-) associated molecule, is expressed on normal B cells. However, RP105-negative B cells increase in peripheral blood from patients with active SLE. RP105 may regulate B-cell activation, and RP105-negative B cells produce autoantibodies and take part in pathophysiology of SLE. It is possible that targeting RP105-negative B cells is one of the treatments of SLE. In this paper, we discuss the RP105 biology and clinical significance in SLE.

PMID: 21941580 [PubMed – indexed for MEDLINE]


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